Esketamine Treatment

Fast-Acting Relief for Treatment-Resistant Depression

SPRAVATO® (Esketamine) is the only FDA-approved nasal spray for adults with treatment-resistant depression that can be taken with or without an oral antidepressant, for rapid improvement of depressive symptoms and reduction in suicidal ideations.

Esketamine is a derivative of Ketamine and it can help reduce depression symptoms when antidepressants haven’t worked well for you. Unlike other antidepressants it has unique mechanism of action by working on NMDA receptors.

What Is Spravato®?

Spravato® (esketamine) is a nasal spray medication administered under medical supervision in the office setting. Unlike standard antidepressants, it works on the brain’s NMDA receptors to enhance the “neuroplasticity” to restore healthy brain connections and improvement in depression symptoms.

Spravato Treatment is FDA approved and covered by most insurance plans, whereas IV infusion treatment is also effective, but it is not FDA approved and not covered by your insurance plan.

Studies show many patients begin to feel symptom improvement within 24–48 hours after treatment.

What to Expect for Receiving Spravato Treatment:

Spravato treatment is covered by most insurance plans.

Consultation: Meet with Dr. Gupta to determine if you’re a candidate for Spravato® therapy.
Insurance Verification: We’ll assist in confirming your coverage through the Spravato® program.
Treatment Session:
- Administered intranasally under direct supervision by Dr. Gupta and trained medical staff.
- Vital signs and your experiences are continuously monitored.
- Each session lasts about two hours in a comfortable, private office setting.
After Treatment:
- You’ll need someone to drive you home (or arrange a ride).
- Most patients describe the experience as relaxing and well-tolerated.

Possible Side Effects

Most side effects are temporary and mild, including:

Dissociation or “spaced-out” feeling
Dizziness or lightheadedness
Nausea or mild headache
Temporary rise in blood pressure
Fatigue or drowsiness

If you have a history of hypertension, cardiovascular disease, or sleep apnea, please inform Dr. Gupta before beginning treatment.

Safety Considerations

Spravato® is:

FDA-approved for adults with treatment-resistant depression.
Administered only in certified Spravato® treatment centers, centers, under REMS program.
Not recommended for patients who are pregnant, breastfeeding, or under 18 years of age.

Find Out if Spravato® Is Right for You

If you’ve tried two or more antidepressants without success, you may be a candidate for Spravato® therapy.

Schedule a consultation with Dr. Adarsh Gupta to discuss whether this innovative, fast-acting treatment could help you reclaim balance and hope.

Take the Next Step

At Sleep, TMS & Wellness Psychiatry, Dr. Adarsh Gupta carefully reviews each patient’s medical history and imaging before starting treatment to ensure safety and suitability. Call (516) 684-9535 to learn more or book your appointment.